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oncocytic mucoepidermoid carcinoma

Tuesday 4 November 2008

Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Oncocytic MEC (OMEC) has been rarely reported with previous cases suggesting they are largely cystic low-grade neoplasms with a favorable prognosis.

The differential diagnosis of OMEC includes numerous oncocytic/"oncocytoid" neoplasms. Some are benign while others are aggressive.

Synopsis

- sex ratio 1/1
- age range : 30 to 79 years
- localization: parotid, sublingual gland, hard palate and neck.
- minimal cystic content
- infiltrative
- solid
- focal mucin production
- oncocytic cells

MAML2 FISH detection

- Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas (21777943)

  • 71% of oncocytic mucoepidermoid carcinomas showed a MAML2 rearrangement by fluorescence in situ hybridization.
  • No correlation was seen between rearrangement status and histologic grade, growth pattern, or p63 staining pattern.
  • MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic lesions.

See also

- mucoepidermoid carcinoma

References

- Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. García JJ, Hunt JL, Weinreb I, McHugh JB, Barnes EL, Cieply K, Dacic S, Seethala RR. Hum Pathol. 2011 Dec;42(12):2001-9. PMID: 21777943}

- Weinreb I, Seethala RR, Perez-Ordoñez B, Chetty R, Hoschar AP, Hunt JL. Oncocytic Mucoepidermoid Carcinoma: Clinicopathologic Description in a Series of 12 Cases. Am J Surg Pathol. 2008 Oct 28. PMID: 18971778