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Tuesday 26 May 2009

Pseudolipomatosis is an artifactual microscopic change in tissues that resembles fatty infiltration, most often described in the gastrointestinal tract.

The fatlike spaces represent air or gas bubbles that enter the mucosa through microscopic ruptures secondary to gaseous insufflation.

Pseudolipomatosis could derive from air that is almost invariably introduced into the uterus during media insufflation for hysteroscopy, creating a bubble under pressure. (19440147)

The air enters tissues either through lining microruptures or during the biopsy procedure.

Pseudolipomatosis is a relatively common, easily overlooked finding in hysteroscopically derived specimens that may be misdiagnosed when prominent.


- Pseudolipomatosis in Hysteroscopically Resected Tissues From the Gynecologic Tract: Pathologic Description and Frequency. Unger ZM, Gonzalez JL, Hanissian PD, Schned AR. Am J Surg Pathol. 2009 May 13. PMID: 19440147