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inherited ossifying diseases

Wednesday 30 September 2009

Inherited ossifying disease

Inherited ossifying diseases are relatively uncommon diseases leading ta a great disability and life-threatening complications.

The fibrodysplasia ossificans progressiva is characterized by the association of skeletal abnormalities mainly in great toes, and enchondral ossifications in tendons and muscles. BMP dysregulation seems to be the main underlying mechanism of the heterotopic ossifications. The genetic basis remain controversial between a mutation on chromosome 4 or 17.

Progressive Osseous Heteroplasia (HOP), more recently described, shares some similarities with Albrights hereditary osteodystrophy. In HOP, the intramembranous ossifications progressively developped from the dermis to the deeper layer. The genetic abnormality involved the GNAS1 gene leading to an inactivation of the alpha subunit of the G protein-complex.

Some therapeutic approaches have been tried: angiogenesis inhibition, mast cell inhibition; others remained in project: BMP 4 inhibition; actually there is no proved efficacy of any of them.

References

- Inherited ossifying diseases. Job-Deslandre C. Joint Bone Spine. 2004 Mar;71(2):98-101. PMID: 15116703