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osseous benign fibrous histiocytoma

Tuesday 8 December 2009

benign fibrous histiocytoma of bones; benign fibrous histiocytoma of bone


Definition: This lesion is the microscopically the same as "metaphyseal fibrous defect" (cortical defect) and "non-ossifying fibroma" of bone. Their clinical and radiological features are rather different, however.


- storiform pattern of spindled cells
- frequent foam cells
- foam cells with delicate fibrous stroma and reactive bone
- variable benign multinucleated giant cells
- resembles cutaneous counterpart

Digital cases

- JRC:4610 : M, 33 y/o. Bone, maxilla. Fibrous histiocytoma
- JRC:4609 : F - Age: 58 y/o; Organ: Bone, femur; Diagnosis: Fibrous histiocytoma; After giant cell tumor;

Differential diagnosis

- non-ossifying fibroma / metphyseal fibrous defect / fibrous cortical defect
- atypical benign fibrous histiocytoma (Unni)
- malignant fibrous histiocytoma of bone (MFH of bone)
- desmoplastic fibroma
- low-grade fibrosarcoma
- late stage of eosinophilic granuloma (Langerhans cell histiocytosis )
- brown tumor of hyperparathyroidism
- giant cell tumor of bone
- osseous xanthoma

- non-ossifying fibroma / metphyseal fibrous defect

  • similar histology but characteristic radiologic findings,
  • usually younger than age 20 years,
  • metaphysis of long bones

See also

- benign fibrous histiocytoma
- osseous benign tumors / benign tumors of bones
- osseous cortical tumors / cortical tumors of bones


- Benign fibrous histiocytoma of bone. Clarke BE, Xipell JM, Thomas DP. Am J Surg Pathol. 1985 Nov;9(11):806-15. PMID: 3000203