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Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Amplifications > Regional amplifications > 12p13 amplification

12p13 amplification

Tuesday 2 February 2010

Driver genes



- pediatric malignant astrocytoma (20068183)


- Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Schiffman JD, Hodgson JG, VandenBerg SR, Flaherty P, Polley MY, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD. Cancer Res. 2010 Jan 15;70(2):512-9. PMID: 20068183