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9q21 MIM.600998 HGNC:4390 Entrez:2776

Thursday 25 February 2010

Guanine nucleotide-binding proteins (GNs), or G-proteins, are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways.

Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit (GNAs) resulting in a conformational change and dissociation of the complex.

The G protein alpha and beta-gamma subunits (GNBs and GNGs) are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit (GNAs).

G-alpha-q (GNAQ) is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta-3 (PLCB3) (MIM.600230).