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host defence genes

Sunday 7 March 2010

Pathogens have always been a major cause of human mortality, so they impose strong selective pressure on the human genome.

Data from population genetic studies, including genome-wide scans for selection, are providing important insights into how natural selection has shaped immunity and host defence genes in specific human populations and in the human species as a whole.

References

- From evolutionary genetics to human immunology: how selection shapes host defence genes. Barreiro LB, Quintana-Murci L. Nat Rev Genet. 2010 Jan;11(1):17-30. PMID: 19953080