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differentiated adamantinoma

Wednesday 2 June 2010

Digital case

- JRC:3170 : Classic adamantinoma of the tibia.

Differential diagnosis

- osteofibrous dysplasia (ossifying fibroma)


- trisomy 7
- trisomy 8
- trisomy 12
- trisomy 19
- tumoral trisomy 21


It has been surmised that osteofibrous dysplasia (OFD) (ossifying fibroma) and adamantinoma are on a continuum with osteofibrous dysplasia-like adamantinoma representing an intermediate step between the two lesions.

Findings indicate that osteofibrous dysplasia, differentiated adamantinoma, and adamantinoma, should be regarded as related conditions. However, only rarely does a case of osteofibrous dysplasia or differentiated adamantinoma eventually act in a malignant fashion.

Genetic studies have also pointed to a relationship between OFD and adamantinoma in that the tumors have been found to share recurrent trisomies (chromosomes 7, 8, 12, and 21).

See also

- adamantinoma

  • dedifferentiated adamantinoma

- fibrous tumors of bones