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low-grade osteosarcomas

Thursday 8 July 2010

Parosteal osteosarcoma and low-grade central osteosarcoma are two types of low-grade osteosarcoma that show similar clinical behaviors, histological features, and genetic background (ie, amplified sequences of 12q13-15, including MDM2 and CDK4).

Low-grade osteosarcomas are often confused with benign lesions.

Types

- parosteal osteosarcoma
- low-grade central osteosarcoma

Immunochemistry

- The combination of MDM2 or CDK4 shows 100% sensitivity and 97.5% specificity for the diagnosis of low-grade osteosarcoma. (20601938)

  • MDM2 and CDK4 immunostains reliably distinguish low-grade osteosarcoma from benign histological mimics, and their combination may serve as a useful adjunct in this difficult differential diagnosis. (20601938)

References

- Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. Yoshida A, Ushiku T, Motoi T, Shibata T, Beppu Y, Fukayama M, Tsuda H. Mod Pathol. 2010 Jul 2. PMID: 20601938

- Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. Mejia-Guerrero S, Quejada M, Gokgoz N, Gill M, Parkes RK, Wunder JS, Andrulis IL. Genes Chromosomes Cancer. 2010 Jun;49(6):518-25. PMID: 20196171