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dedifferentiated adamantinoma

Wednesday 1 September 2010

Adamantinomas of the long bones are low-grade malignant tumours. They seem to be related to osteofibrous dysplasia with a mesenchymal-to-epithelial transformation.

Synopsis

- 2 histologic patterns:

  • epithelial nests with a basaloid arrangement and positive for pankeratins and so-called glandular keratins
  • sarcomatoid component, negative for these epithelial markers.

See also

- classic adamantinoma
- sarcomatoid transformation

References

- Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype. Izquierdo FM, Ramos LR, Sánchez-Herráez S, Hernández T, de Alava E, Hazelbag HM. Am J Surg Pathol. 2010 Sep;34(9):1388-92. PMID: 20717000