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Friday 14 November 2003

Mood disorders, including major depressive disorder and bipolar disorder, are influenced by both genetic and environmental factors.

Hypotheses about the neurobiology of mood disorders have been postulated and putatively associated genes identified.

The immune-related gene encoding purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7) has been genetically associated with major depressive disorder and bipolar disorder.

New candidate genes and emerging gene networks and pathways involved in the aetiology of mood disorders point to a major role for neuronal survival and the adaptive immune systems.

Predisposition loci

- 12q22-12q23.2 (14606042)


- Belmaker RH, Agam G. Major depressive disorder. N Engl J Med. 2008 Jan 3;358(1):55-68. PMID: 18172175

- Harvey M, Belleau P, Barden N. Gene interactions in depression: pathways out of darkness. Trends Genet. 2007 Nov;23(11):547-56. PMID: 17963976

- Camp NJ, Cannon-Albright LA. Dissecting the genetic etiology of major depressive disorder using linkage analysis. Trends Mol Med. 2005 Mar;11(3):138-44. PMID: 15760772