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XX ovotesticular DSD

Thursday 7 October 2010

XX maleness

Differentiation of testicular tissue in 46,XX individuals is seen either in 46,XX males, the majority of them with SRY gene, or in individuals, usually SRY(-), with ovotesticular disorder of sex development (OT-DSD).

Although they are sporadic cases, there are some reports on familial recurrence, including coexistence of XX maleness and OT-DSD in the same family.

Both XX maleness and XX OT-DSD are different manifestations of the same disorder of gonadal development.

See also

- XX maleness

Open References

- Sex determination and disorders of sex development according to the revised nomenclature and classification in 46,XX individuals. Kousta E, Papathanasiou A, Skordis N. Hormones (Athens). 2010 Jul-Sep;9(3):218-131. PMID: 20688619 [Free]

- XX Maleness and XX true hermaphroditism in SRY-negative monozygotic twins: additional evidence for a common origin. Maciel-Guerra AT, de Mello MP, Coeli FB, Ribeiro ML, Miranda ML, Marques-de-Faria AP, Baptista MT, Moraes SG, Guerra-Júnior G. J Clin Endocrinol Metab. 2008 Feb;93(2):339-43. PMID: 18056774 (Free)