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ALK-rearranged tumors

Tuesday 14 June 2011

ALK-associated tumors

The anaplastic lymphoma kinase (ALK) gene has recently been implicated in subsets of pulmonary, esophageal, breast, and colon cancers.

These findings strengthen the importance of molecular classification of carcinomas across different organ sites, especially considering the evolving targeted anticancer therapies with ALK inhibitors.

Tumors

- ALK-associated colonic adenocarcinoma
- ALK-associated esophageal carcinoma
- ALK-associated mammary adenocarcinoma
- ALK-associated pulmonary carcinoma
- ALK-associated renal cell carcinoma
- ALK-associated anaplastic lymphoma
- ALK-associated inflammatory myofibroblastic tumor

References

- Comprehensive Histologic Analysis of ALK-Rearranged Lung Carcinomas. Yoshida A, Tsuta K, Nakamura H, Kohno T, Takahashi F, Asamura H, Sekine I, Fukayama M, Shibata T, Furuta K, Tsuda H. Am J Surg Pathol. 2011 Aug;35(8):1226-34. PMID: 21753699

- Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers. Lin E, Li L, Guan Y, Soriano R, Rivers CS, Mohan S, Pandita A, Tang J, Modrusan Z. Mol Cancer Res. 2009 Sep;7(9):1466-76. PMID: 19737969 [Free]

- EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset. Inamura K, Takeuchi K, Togashi Y, Hatano S, Ninomiya H, Motoi N, Mun MY, Sakao Y, Okumura S, Nakagawa K, Soda M, Choi YL, Mano H, Ishikawa Y. Mod Pathol. 2009 Apr;22(4):508-15. PMID: 19234440 [Free]

- ALK rearrangement in sickle cell trait-associated renal medullary carcinoma. Mariño-Enríquez A, Ou WB, Weldon CB, Fletcher JA, Pérez-Atayde AR. Genes Chromosomes Cancer. 2011 Mar;50(3):146-53. PMID: 21213368

- Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum. Debelenko LV, Raimondi SC, Daw N, Shivakumar BR, Huang D, Nelson M, Bridge JA. Mod Pathol. 2011 Mar;24(3):430-42. PMID: 21076462