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nodal marginal zone B-cell lymphoma

Tuesday 6 December 2011

Digital case

- HPC:312 - Nodal localization of a marginal zone B-cell lymphoma (MZBCL) (nodal localization of a MALT lymphoma)

Microscopy

The neoplastic cells are frequently a mix of classic monocytoid B-cells with small somewhat folded nuclei and abundant cytoplasm, small lymphocytes with little cytoplasm, large lymphocytes, and variable numbers of plasma cells and plasmacytoid lymphocytes.

Follicular colonization may be present as well as follicles resembling those of progressive transformation of follicular centers.

Immunochemistry

Most cases have CD5–CD10-phenotype with monotypic surface Ig.

Many have monotypic cytoplasmic immunoglobulin in plasma cells on paraffin immunoperoxidase stains.

Pediatric nodal marginal zone lymphoma

Pediatric nodal marginal zone lymphoma, like its adult counterpart, can be particularly diffi ult to diagnose in that these lymphomas often only partially efface architecture with an interfollicular distribution.

Like pediatric follicular lymphoma, these patients are predominantly males with limited stage disease (usually cer-vical nodes) and have an apparently good prognosis.

See also

- marginal zone B-cell lymphoma (MZBCL)
- MALT lymphoma