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prostatic tumors

Tuesday 7 February 2012

prostate tumours

WHO histological classification of tumours of the prostate

- prostatic epithelial tumors

  • prostatic glandular tumors
    • prostatic adenocarcinoma (prostatic acinar adenocarcinoma) ICD-0:8140/31
      • prostatic atrophic adenocarcinoma
      • prostatic pseudohyperplastic adenocarcinoma
      • prostatic foamy adenocarcinoma
      • prostatic colloid adenocarcinoma ICD-0:8480/3
      • prostatic signet ring adenocarcinoma ICD-0:8490/3
      • prostatic oncocytic adenocarcinoma ICD-0:8290/3
      • prostatic lymphoepithelioma-like adenocarcinoma ICD-0:8082/3
    • prostatic carcinoma with spindle cell differentiation (prostatic spindle cell carcinoma) : (carcinosarcoma, sarcomatoid carcinoma) ICD-0:8572/3
    • prostatic intraepithelial neoplasia (PIN)
    • prostatic intraepithelial neoplasia, grade III (PIN III) ICD-0:8148/2
    • prostatic ductal adenocarcinoma ICD-0:8500/3
      • prostatic cribriform adenocarcinoma ICD-0:8201/3
      • prostatic papillary adenocarcinoma ICD-0:8260/3
      • prostatic solid adenocarcinoma ICD-0:8230/3

- prostatic neuroendocrine tumors

  • prostatic endocrine differentiation within adenocarcinoma ICD-0:8574/3
  • prostatic carcinoid tumour ICD-0:8240/3
  • prostatic small cell carcinoma ICD-0:8041/3
  • prostatic paraganglioma ICD-0:8680/1
  • prostatic neuroblastoma ICD-0:9500/3

- prostatic stromal tumors

  • prostatic stromal tumour of uncertain malignant potential ICD-0:8935/1
  • prostatic stromal sarcoma ICD-0:8935/3

- prostatic mesenchymal tumors

  • prostatic leiomyosarcoma ICD-0:8890/3
  • prostatic thabdomyosarcoma ICD-0:8900/3
  • prostatic chondrosarcoma ICD-0:9220/3
  • prostatic angiosarcoma ICD-0:9120/3
  • prostatic malignant fibrous histiocytoma ICD-0:8830/3
  • prostatic malignant peripheral nerve sheath tumour ICD-0:9540/3
  • prostatic hemangioma ICD-0:9120/0
  • prostatic chondroma ICD-0:9220/0
  • prostatic leiomyoma ICD-0:8890/0
  • prostatic granular cell tumour ICD-0:9580/0
  • prostatic hemangiopericytoma ICD-0:9150/1
  • prostatic solitary fibrous tumour ICD-0:8815/0

- prostatic mematolymphoid tumors

  • prostatic lymphoma
  • prostatic leukemia

- prostatic miscellaneous tumours

- prostatic metastatic tumours
- prostatic tumors of the seminal vesicles

- prostatic epithelial tumors

  • prostatic adenocarcinoma ICD-0:8140/3
  • prostatic cystadenoma ICD-0:8440/0

- prostatic mixed epithelial and stromal tumors

  • prostatic malignant mixed epithelial and stromal tumors
  • prostatic benign mixed epithelial and stromal tumors

- prostatic mesenchymal tumours

  • prostatic leiomyosarcoma ICD-0:8890/3
  • prostatic angiosarcoma ICD-0:9120/3
  • prostatic liposarcoma ICD-0:8850/3
  • prostatic malignant fibrous histiocytoma ICD-0:8830/3
  • prostatic solitary fibrous tumour ICD-0:8815/0
  • prostatic hemangiopericytoma ICD-0:9150/1
  • prostatic leiomyoma ICD-0:8890/0

- prostatic miscellaneous tumours

  • prostatic choriocarcinoma ICD-0:9100/3
  • prostatic male adnexal tumour of probable Wolffian origin

- prostatic metastatic tumors

TNM classification of carcinomas of the prostate

T – Primary tumour

- TX Primary tumour cannot be assessed
- T0 No evidence of primary tumour
- T1 Clinically inapparent tumour not palpable or visible by imaging
- * T1a Tumour incidental histological finding in 5% or less of tissue
- * T1b Tumour incidental histological finding in more than 5% of tissue
- * T1c Tumour identified by needle biopsy (e.g., because of elevated

- T2 Tumour confined within prostate (Tumour found in one or both lobes by needle biopsy, but not palpable or visible by imaging, is classified as T1c.)
- * T2a Tumour involves one half of one lobe or less
- * T2b Tumour involves more than half of one lobe, but not both lobes
- * T2c Tumour involves both lobes

- T3 Tumour extends beyond the prostate (Invasion into the prostatic apex yet not beyond the prostate is not classified as T3, but as T2.)
- * T3a Extracapsular extension (unilateral or bilateral)
- * T3b Tumour invades seminal vesicle(s)

- T4 Tumour is fixed or invades adjacent structures other than sem
inal vesicles: bladder neck, external sphincter, rectum, levator
muscles, or pelvic wall (Microscopic bladder neck involvement at radical prostatectomy should be classified as T3a.)

Note: There is no pT1 category because there is insufficient tissue to assess the highest pT category.

N – Regional lymph nodes

- NX Regional lymph nodes cannot be assessed
- N0 No regional lymph node metastasis
- N1 Regional lymph node metastasis

Note: Metastasis no larger than 0.2cm can be designated pN1mi

M – Distant metastasis

- MX Distant metastasis cannot be assessed
- M0 No distant metastasis
- M1 Distant metastasis
- M1a Non-regional lymph node(s)
- M1b Bone(s)
- M1c Other site(s)

G Histopathological grading

GX Grade cannot be assessed
G1 Well differentiated (Gleason 2-4)
G2 Moderately differentiated (Gleason 5-6)
G3–4 Poorly differentiated/undifferentiated (Gleason 7-10)

Stage grouping

Stage I T1a N0 M0 G1
Stage II T1a N0 M0 G2, 3–4
T1b, c N0 M0 Any G
T1, T2 N0 M0 Any G
Stage III T3 N0 M0 Any G
Stage IV T4 N0 M0 Any G
Any T N1 M0 Any G
Any T Any N M1 Any G

See also

- prostatic non-epithelial tumors

  • prostatic mesenchymal tumors

- Cancer
- Tumors


- Non-epithelial neoplasms of the prostate. Paner GP, Aron M, Hansel DE, Amin MB. Histopathology. 2012 Jan;60(1):166-86. PMID: 22212085