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signet-ring PIN

Thursday 16 February 2012

Signet-ring variant.

High grade prostatic intraepithelial neoplasia (PIN) with signet-ring cells is exceedingly rare with only three reported cases. In all cases signet-ring cell PIN was admixed with adjacent, invasive signet-ring carcinoma.

Histologically, cytoplasmic vacuoles displace and indent PIN cell nuclei.

The vacuoles are mucin-negative by histochemical staining (mucicarmine, Alcian blue, PAS)