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inverted PIN

Thursday 16 February 2012

The inverted, or hobnail, variant is typified by polarization of enlarged secretory cell nuclei toward the glandular lumen of high-grade PIN glands with tufted or micropapillary architectural patterns.

The frequency was estimated to be less than 1% of all PIN cases.

In six of 15 reported needle biopsy cases, there was associated usual, small acinar Gleason score 6-7 adenocarcinoma.