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zebrafish
Friday 21 November 2003
The zebrafish has become a widely used model organism because of its fecundity, its morphological and physiological similarity to mammals, the existence of many genomic tools and the ease with which large, phenotype-based screens can be performed.
Because of these attributes, the zebrafish might also provide opportunities to accelerate the process of drug discovery. By combining the scale and throughput of in vitro screens with the physiological complexity of animal studies, the zebrafish promises to contribute to several aspects of the drug development process, including target identification, disease modelling, lead discovery and toxicology.
Video
early zebrafish development
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Open References
The emerging use of zebrafish to model metabolic disease. Seth A, Stemple DL, Barroso I. Dis Model Mech. 2013 Sep-Oct;6(5):1080-8. doi : 10.1242/dmm.01134 PMID: 24046387 [Free]
References
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Ingham PW. Zebrafish genetics and its implications for understanding vertebrate development. Hum Mol Genet. 1997;6(10):1755-60. PMID: 9300668