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ciliated cell metaplasia

Sunday 4 March 2012

Ciliated cells may develop deep to areas of intestinal metaplasia.

In the mucosa of patients with gastric ulcers, dysplasia, or adenocarcinomas; and at sites away from the main lesion.

The ciliated cells show some evidence of an antral phenotype, as demonstrated by their pepsinogen group II activity.

The cilia in the cells often are structurally abnormal.

The ciliated cells line cystically dilated glands, where they may represent an adaptive mechanism aimed at expelling semifluid viscous material and inflammatory cells from the cysts.

As cysts enlarge, the intrinsic pressure ofthe retained mucus results in cellular atrophy and ciliary disappearance.