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digestive food granuloma

Tuesday 6 March 2012

The presence ofa gastric granuloma should always promptthe search for a foreign body.

Foreign body granulomas form when mucosal defects allow small food particles or other substances access to the submucosa.

These foreign body granulomas are usually easily distinguished from the granulomas seen in the disorders discussed above.

They frequently have palisades of histiocytes and foreign body giant cells.

Acid leads to necrosis, increasing the size ofthe mucosal defect, thereby allowing more food to enter.

These food particles (particularly insoluble cereals) lying deep in the gastric wall elicit the granulomas.

They appear as amorphous eosinophilic masses, sometimes containing vegetable cells recognizable by their thick, brick-like cell walls.

Palisading epithelioid histiocytes and foreign body giant cells surround the food particles.

The granulomas may become fibrotic or calcified.


- pulse granuloma
- gastric food granuloma
- intestinal food granuloma
- colorectal food granuloma