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allergic gastritis

Tuesday 6 March 2012

The stomach is commonly involved in food-induced hypersensitivity reactions, especially in children.

Allergic gastritis is usually a manifestation of a more extensive allergic gastroenteritis.

Patients present with anorexia, nausea, vomiting, diarrhea, weight loss, peripheral eosinophilia, elevated serum IgE, a personal or family allergic history, and epigastric pain.

Direct mucosal challenge with a specific antigen in allergic individuals produces gastric mucosal edema, erythema, and petechial hemorrhages.

Mast cell degranulation recruits neutrophils followed by mononuclear cells.

A diffuse eosinophilic infiltrate involving the lamina propria and the superficial and pit epithelium causes epithelial damage with focal denudation and erosions, mucin depletion, and concurrent regeneration.

The mucosa surrounding the erosions shows foveolar hyperplasia.

Excessive histamine release can lead to gastric gland hyperplasia.

See also

- gastritis

  • eosinophilic gastritis