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gastric isolated hamartomatous polyp

Monday 12 March 2012

Microscopy

Isolated hamartomatous polyps consist of a prominent sub-mucosal mass of haphazardly arranged oxyntic glands in a framework of smooth muscle tissue and occasional focal accumulations of mature lymphoid tissue.

The entire lesion is supported by normal lamina propria.

The glands may appear normal or be cystically dilated.

One also sees mucous cells resembling foveolar epithelium as well as rare antral or cardiac-type glands containing endocrine cells indigenous to the mucosal site.

Differential diagnosis

The lesions differ from those seen in Peutz-Jeghers syndrome, which are usually not submucosal lesions but more mucosally based with possible submucosal extensions.

Additionally, the arborizing muscle bundles seen in Peutz-Jeghers polyps are typically absent in isolated gastric hamartomas.

See also

- gastric polyps