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colorectal mixed adenoneuroendocrine carcinoma

Thursday 22 March 2012


Colorectal poorly differentiated neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine carcinomas (MANECs) are well-recognized entities generally known to be associated with biological aggressiveness and poor patient survival.

These neoplasms show a heterogenous spectrum of morphologic and immunohistochemical features; however, only large-cell subtype, significant peritumoral lymphoid reaction, CD117 immunoreactivity, vascular invasion, and MSI/CIMP+ status were significantly correlated with prognosis on univariable analysis.

Furthermore, vascular invasion and CD117 immunoreactivity are independent prognostic markers on multivariable analysis.


- Colorectal Poorly Differentiated Neuroendocrine Carcinomas and Mixed Adenoneuroendocrine Carcinomas: Insights Into the Diagnostic Immunophenotype, Assessment of Methylation Profile, and Search for Prognostic Markers. La Rosa S, Marando A, Furlan D, Sahnane N, Capella C. Am J Surg Pathol. 2012 Feb 3. PMID: 22314183