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NUT-associated pulmonary carcinoma

Friday 23 March 2012

pulmonary NUT midline carcinoma, pulmonary NUT-associated midline carcinoma, pulmonary NUT-associated carcinoma


These tumors are diffusely positive for p63 and NUT expression and are partially positive for various cytokeratins.

Reverse transcription polymerase chain reaction analysis and subsequent direct sequencing reveal that the bromodomain-containing protein 4-NUT chimeric gene is present in tumor tissue of both patients, leading to a diagnosis of NMC.

See also

- NUT-associated carcinomas

  • NUT-associated midline carcinoma

Open References

- NUT expression in primary lung tumours. Lund-Iversen M, Grøholt KK, Helland Å, Borgen E, Brustugun OT. Diagn Pathol. 2015 Sep 5;10(1):156. doi : 10.1186/s13000-015-0395-9 PMID: 26341600 (Free)


- NUT Midline Carcinoma: Report of 2 Cases Suggestive of Pulmonary Origin. Tanaka M, Kato K, Gomi K, Yoshida M, Niwa T, Aida N, Kigasawa H, Ohama Y, Tanaka Y. Am J Surg Pathol. 2012 Mar;36(3):381-8. PMID: 22301500