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CD133+ prostate cells

Thursday 12 April 2012

Prostate stem cells in benign and tumor tissue express the cell surface marker CD133, but these cells have not been well characterized.

CD133+ cells freshly isolated from benign prostate tissue exhibited an expression profile characteristic of a putative stem/progenitor cell population, with transcripts involved in biological processes ranging from development and ion homeostasis to cell communication.

The profile of CD133- cells is consistent with that of a transit amplifying population, suggesting up-regulated proliferation and metabolism.

Comparison of benign populations to those from HRPC showed some similarities between CD133+ profiles but also revealed significant differences that provide a tumor-specific pattern, which included evidence of increased metabolic activity and active proliferation.

Expression of some markers in prostate tumors has been found, including the oligodendrocyte lineage transcription factor OLIG1.

References

- Expression profiling of CD133+ and CD133- epithelial cells from human prostate. Shepherd CJ, Rizzo S, Ledaki I, Davies M, Brewer D, Attard G, de Bono J, Hudson DL. Prostate. 2008 Jun 15;68(9):1007-24. PMID: 18398820