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colorectal neural lesions

Monday 31 December 2012

Neural lesions of the colon

Neural lesions of the colon are a rare group of colorectal disorders that may frequently present as small polyps.

This heterogeneous group includes ganglion cells and nerve sheath tumors that have been frequently described as multiple lesions in association with inherited syndrome such as:
- von Recklinghausen (or type 1) neurofibromatosis (NF-1),
- multiple endocrine neoplasia type 2B (MEN 2B),
- Cowden syndrome.

Moreover, sporadic forms of these neural lesions have been reported including:
- solitary colonic polypoid ganglioneuroma,
- solitary colonic neurofibroma,
- mucosal benign epithelioid nerve sheath tumors.

Recently, Gibson and Hornick have analysed 26 cases of colorectal polypoid lesions comprising pure Schwann cell proliferation, which were different from gastrointestinal tract (GI) schwannomas, and with no association with inherited syndromes. This entity was designated as mucosal Schwann cell hamartoma [2009].


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- Gibson JA, Hornick JL. Mucosal Schwann cell "hamartoma": clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas. Am J Surg Pathol. 2009;33:781–7. doi : 10.1097/PAS.0b013e31818dd6ca

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- Mendez IM, Pereda T, Rodriguez FJ, Funez R, Sanchez A. Solitary colonic polypoid ganglioneuroma. Diagn Pathol. 2008;3:20. doi : 10 1186/1746-1596-3-20

- Panteris V, Vassilakaki T, Vaitsis N, Elemenoglou I, Mylonakou I, Karamanolis DG. Solitary colonic neurofibroma in a patient with transient segmental colitis: case report. World J Gastroenterol. 2005;11:5573–6

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- Lewin MR, Dilworth HP, Abu Alfa AK, Epstein JI, Montgomery E. Mucosal benign epithelioid nerve sheath tumors. Am J Surg Pathol. 2005;29:1310–5. doi : 10.1097/01.pas.0000162762.03068 7a