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hepatic peritumoral hyperplasia

Thursday 10 January 2013

peritumoral hyperplasia of the liver

Several cases of focal nodular hyperplasia (FNH) or similar hyperplastic lesions have been reported adjacent to hepatic neoplasms, including hepatocellular carcinoma, epithelioid haemangioendothelioma and hepatoblastoma.

PTH is a hyperplastic response to increased blood flow in the peritumoral parenchyma.

The increased flow occurs when portal vein invasion by a hypervascular tumour causes arterio-portal shunting.

While PTH shares some morphological features with FNH, it lacks the defining nodular architecture, central scar and bile ductules.

PTH may be related pathophysiologically to FNH, but should be classified as a separate entity because of its distinct morphology and peritumoral location.


- Peritumoral hyperplasia of the liver: a response to portal vein invasion by hypervascular neoplasms. Arnason T, Fleming KE, Wanless IR. Histopathology. 2012 Sep 17. doi : 10.1111/his.12032 PMID: 23240735