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Home > E. Pathology by systems > Digestive system > Colon and rectum > colorectal medullary carcinoma

colorectal medullary carcinoma

Friday 15 February 2013

Definition: Colorectal medullary carcinoma is extremely rare, constituting approximately 5-8 cases for every 10,000 colorectal cancers diagnosed, with a mean annual incidence of 3.47 (±0.75) per 10 million population.

This tumor is characterized by sheets of epithelioid neoplastic cells with large vesicular nuclei, prominent nucleoli, and abundant cytoplasm.

It typically has a pushing border on resection specimens, and is characteristically associated with marked tumorinfiltrating lymphocytes.

Medullary carcinoma is a distinctive histologic subtype that is strongly associated with MSI-H.

It usually has a favorable prognosis despite its poorly differentiated or undifferentiated histology.

See also

- digestive medullary carcinoma
- colorectal carcinomas