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cutaneous angioleiomyoma

Tuesday 26 February 2013

skin angioleiomyoma

Definition : Angioleiomyoma are common typically painful,benign neoplasm that originates from smooth muscle cells of arterial or venous walls and contains thick-walled vessels.


- well-circumscribed, bundles of benign smooth muscle cells with numerous admixed vessels of varying sizes. Usually lower extremity site




These are usually located in the subcutis and deep dermis of the extremities, particularly the lower leg. Cases have been reported on the the head and upper trunk and these are often painless.

Cases have been reported at unusual sites:
- i) Oral angioleiomyomas are usually located on the lip, palate, buccal mucosa and tongue, mandible, floor of mouth, and gingiva.
- ii) Tonsil
- iii) Auricle
- iv) Within the scrotum, structures such as the epididymis, spermatic cord, dartos fascia, and blood vessels could be sites of origin of angioleiomyoma.


Presents as a slow growing , firm, gray white, round to oval nodules (usually less than 2cm in diameter).


- Well circumscribed and encapsulated tumour is usually noted in the lower dermis and subcutis.
- There are interlacing bundles of smooth muscle fibres between vascular channels.
- The vessel walls (veins) display layers of smooth muscle fibres. These muscle fibres appear to merge peripherally into the intervascular muscle fibres.
- These vessels may have slit-like or dilated lumen.
- Degenerative changes may be present including vascular thrombosis, stromal hyalinization, myxoid changes, dystrophic calcification and nuclear atypia.


- Solid
- Cavernous
- Venous
- Epithelioid
- Pleomorphic


The smooth muscle cells express vimentin, desmin and smooth muscle actin.

Note: Angioleiomyoma is often associated with pain. Pain is probably mediated by nerves present in the tumour and in the capsule due to either mechanical stretching or through mast cell mediation.

Other painful tumours of soft tissue and skin are:
- glomus tumour,
- eccrine spiradenoma,
- angiolipoma
- traumatic neuroma.


- Usually occur in the fourth and sixth decade of life.