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GLI1

MIM.165220 12q13.2-q13.3

Monday 28 June 2004

Ci, Cubitus interruptus homolog GLI1, glioma-associated oncogen homolog GLI, GLI

Definition: GLI is a Zinc Finger transcription factor that is the transcription factor of the Hedgehog signaling pathway.

Gli code hypothesis (17845852)

The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape.

Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.

Pathology

- GLI1 fusion in tumors

- GLI amplification in tumors

References

- Ruiz i Altaba A, Mas C, Stecca B. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol. 2007 Sep;17(9):438-47. PMID: 17845852

- Aza-Blanc P, Kornberg TB. Ci: a complex transducer of the hedgehog signal. Trends Genet. 1999 Nov;15(11):458-62. PMID: 10529809

- Bigner, S. H.; Mark, J.; Burger, P. C.; Mahaley, M. S., Jr.; Bullard, D. E.; Muhlbaier, L. H.; Bigner, D. D. : Specific chromosomal abnormalities in malignant human gliomas. Cancer Res. 88: 405-411, 1988.

- Chung, R. Y.; Seizinger, B. R. : Molecular genetics of neurological tumours. J. Med. Genet. 29: 361-367, 1992. PubMed ID : 1320124

- Kinzler, K. W.; Bigner, S. H.; Bigner, D. D.; Trent, J. M.; Law, M. L.; O’Brien, S. J.; Wong, A. J.; Vogelstein, B. : Identification of an amplified, highly expressed gene in a human glioma. Science 236: 70-73, 1987. PubMed ID : 3563490

- Nilsson, M.; Unden, A. B.; Krause, D.; Malmqwist, U.; Raza, K.; Zaphiropoulos, P. G.; Toftgard, R. : Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc. Nat. Acad. Sci. 97: 3438-3443, 2000. PubMed ID : 10725363