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Bowenoid papulosis

Monday 20 May 2013

Bowenoid papulosis consists of one or more indolent, verrucous papules on the genitalia with a clinical resemblance to condyloma acuminatum and a histological resemblance to Bowen’s disease.

HPV-16 is the most frequently detected HPV subtype detected in this condition. It usually responds to local therapies, but recurrences and the development of invasive carcinoma have been reported.

The term ‘penile intraepithelial neoplasia’ (PIN) has been coined to encompass the three preinvasive clinical entities of:
- penile Bowen’s disease
- erythroplasia of Queyrat
- bowenoid papulosis.

Bowenoid papulosis of the genitalia is regarded by some as a variant of Bowen’s disease of the genitalia; although the two conditions may be histologically indistinguishable, features that favor a diagnosis of bowenoid papulosis include numerous mitoses in metaphase, small basophilic inclusions in the cytoplasm of the granular layer, and the presence sometimes of cells with a resemblance to koilocytes.