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nodular basal cell carcinoma

Wednesday 22 May 2013

Nodular type (solid)

Definition: The solid variant, also known as the large nest type, accounts for approxi­mately 70% of all cases. It is composed of islands of cells with peripheral palisading and a haphazard arrangement of the more central cells.

This histological type represents, according to various authors, 30 to 75
% of all BCC. This wide range is influenced to a certain extent by the assignment or exclusion of similar growth types.

The nodular histological type consists of cell islets with a typical peripheral palisading of the cells and chaotic arrangement of the cells in the central region. It can achieve a cystic appearance in microscopy in the case of necrosis of centrally located cells, next to which an accumulation of mucin occurs.

Sometimes the projections of the tumour cells produce a reticular formation. Some authors set apart this cystic and adenoid pattern as special types, other authors include these variants in the nodular variant due to the basic growth pattern.

The fibroepithelial variant is also often included in the nodular type, in which cell nests interconnected with thin strands of cells are lost in the abundant stroma.

Retraction spaces sometimes form between the tumor islands and the surrounding stroma. Ulceration may be present in larger lesions.