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Neuroblasts

Tuesday 25 November 2003

- asymmetric division

In the embryonic central nervous system of the fruit fly Drosophila, most neurons and glial cells are generated by asymmetric division of neural stem cells called neuroblasts.

Several genes have been identified that are required for the establishment of neuroblast polarity, for the asymmetric segregation of cell fate determinants and for the proper orientation and geometry of the mitotic spindle.

See also

- tumoral neuoblasts

  • immature neuroblasts
  • differentiating neuroblasts

References

- Wodarz A. Molecular control of cell polarity and asymmetric cell division in Drosophila neuroblasts. Curr Opin Cell Biol. 2005 Oct;17(5):475-81. PMID: 16099639

- Lin H, Schagat T. Neuroblasts: a model for the asymmetric division of stem cells. Trends Genet. 1997 Jan;13(1):33-9. PMID: 9009846

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