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pigmented spindle-cell tumors of the lymph node

Friday 9 January 2015

Pigmented spindle-cell tumors of the lymph nodes; anthracosilicotic spindle-cell pseudotumor; pigmented spindle-cell tumors of the lymph node

Pigmented spindle-cell tumors of the lymph nodes have a broad differential diagnosis, including both benign and malignant neoplasms.

Synopsis

- atypical polygonal cells and atypical spindle cells
- bland nuclear features
- abundant cytoplasmic anthracotic pigment

To do

- immunohistochemistry

- Polarization microscopy

  • minute birefringent intracellular crystals consistent with silica.

- Electron microscopy

Differential diagnosis (example)

- spindle-cell melanoma localization
- anthracosilicotic spindle-cell pseudotumor

See also

References

- A case report of anthracosilicotic spindle-cell pseudotumor of mediastinal lymph node: cytologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration. Varghese LR, Stanley MW, Wakely PE Jr, Lucido ML, Mallery S, Bardales RH. Diagn Cytopathol. 2005 Oct;33(4):268-72. PMID: 16138379