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lepidic growth

Monday 13 July 2015

lepidic growth in pulmonary adenocarcinoma, lepidic growth pattern

Tumors

- pulmonary adenocarcinoma

  • pulmonary adenocarcinoma with prominent lepidic spread
  • The percentage of the lepidic component appears to be an independent, significant prognostic factor in a selection of pulmonary AC. (26159539)

- lepidic pulmonary metastasis from cholangiocarcinoma

Images

- Adenocarcinoma with predominant lepidic growth pattern, Case 210

  • https://www.flickr.com/photos/pulmonary_pathology/7146047393
  • Core biopsy: the prominent intra-alveolar growth with papillary projections into the alveoli indicates that this is likely an invasive neoplasm.
  • That this is indeed invasive adenocarcinoma is indicated by the appearance of the mass on the CT scan as well as by a separate small tissue fragment from this specimen showing unequivocal invasive adenocarcinoma.

Open references

- Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma. Vinayanuwattikun C, Le Calvez-Kelm F, Abedi-Ardekani B, Zaridze D, Mukeria A, Voegele C, Vallée M, Purnomosari D, Forey N, Durand G, Byrnes G, Mckay J, Brennan P, Scelo G. Sci Rep. 2016 Aug 22;6:31628. doi : 10.1038/srep31628 PMID: 27545006 Free

- An Autopsy Case of Lepidic Pulmonary Metastasis from Cholangiocarcinoma.
Nagayoshi Y, Yamamoto K, Hashimoto S, Hisatomi K, Doi S, Nagashima S, Kurohama H, Ito M, Takazono T, Nakamura S, Miyazaki T, Kohno S.
Intern Med. 2016;55(19):2849-2853.
PMID: 27725547 Free

Paywall References

- The percentage of lepidic growth is an independent prognostic factor in invasive adenocarcinoma of the lung. Strand TE, Rostad H, Strøm EH, Hasleton P. Diagn Pathol. 2015 Jul 9;10(1):94. PMID: 26159539