- Human pathology

Home > A. Molecular pathology > transmembrane domain proteins

transmembrane domain proteins

Thursday 27 November 2003

Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes.


- G-protein coupled receptors (GPCRs)
- growth factor receptors
- ion channels
- transporters
- metabolic enzymes


-  pathology of G-protein coupled receptors (GPCRs)
- pathology of growth factor receptors
- pathology of ion channels (channelopathies)
- pathology of transporters
- pathology of metabolic enzymes


- Cobbold C, Monaco AP, Sivaprasadarao A, Ponnambalam S. Aberrant trafficking of transmembrane proteins in human disease. Trends Cell Biol. 2003 Dec;13(12):639-47. PMID: 14624842