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aggressive digital papillary adenocarcinoma

Wednesday 23 September 2015


Aggressive digital papillary adenocarcinoma (ADPA) is a rare cutaneous adnexal neoplasm that occurs on the fingers, toes, palms, and soles. It is characterized by aggressive biological behavior, with a relatively high potential for local recurrence (30%-40% of cases) and distant metastasis (up to 14%).

Complete surgical excision is the treatment of choice for ADPA; however, there are no uniform diagnostic guidelines or recognized effective treatments for metastasis, and no therapeutic targets have been identified.

Molecualr biology

- BRAF-V600E (BRAF c.1799T>A p.V600E) mutation


- Next-generation sequencing reveals rare genomic alterations in aggressive digital papillary adenocarcinoma. Bell D, Aung P, Prieto VG, Ivan D. Ann Diagn Pathol. 2015 Aug 28. pii: S1092-9134(15)00132-X. doi : 10.1016/j.anndiagpath.2015.08.002
PMID: 26386519