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complex fibroadenoma

Friday 23 October 2015

Complex fibroadenoma is a sub type of fibroadenoma harbouring one or more of the following features:
- epithelial calcifications
- papillary apocrine metaplasia
- sclerosing adenosis and
-  cysts larger than 3 mm

They fall under the broad group of "adenomatous breast lesions".

Complex fibroadenomas are often smaller than simple fibroadenomas (1.3 cm compared with 2.5 cm in simple fibroadenomas).

When histopathology on core biopsy reveals a higher-risk lesion, such as atypical lobular hyperplasia, excisional biopsy may be indicated to rule out malignancy.



Open references

- Lobular intraepithelial neoplasia arising within breast fibroadenoma. Limite G, Esposito E, Sollazzo V, Ciancia G, Formisano C, Di Micco R, De Rosa D, Forestieri P. BMC Res Notes. 2013 Jul 12;6:267. doi : 10.1186/1756-0500-6-267 PMID: 23849288 (Free)

- Histopathology of fibroadenoma of the breast. Kuijper A, Mommers EC, van der Wall E, van Diest PJ. Am J Clin Pathol. 2001 May;115(5):736-42. PMID: 11345838 (Free)

- Long-term risk of breast cancer in women with fibroadenoma. Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD Jr, Rados MS, Schuyler PA. N Engl J Med. 1994 Jul 7;331(1):10-5. PMID: 8202095 (Free)