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lobular neoplasia

Friday 20 November 2015

mammary lobular neoplasia; lobular neoplasia of the breast

Definition : Lobular neoplasia encompasses a spectrum of disease, including atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS).

It is continuum from what was formerly known as atypical lobular hyperplasia (ALH) through to lobular carcinoma in situ (LCIS).

Although classic forms of lobular neoplasia are predominantly heralded as a risk marker, the pleomorphic form of lobular carcinoma in situ (LCIS) is generally regarded as a more aggressive subtype and a possible cancer precursor, and thus is treated in a manner more similar to ductal carcinoma in situ (DCIS) than classic forms of lobular neoplasia.

Correct classification of classic lobular neoplasia and pleomorphic lobular carcinoma in situ (LCIS) is critical because of differences in clinical management, with current treatment strategies focused on risk reduction for patients with classic lobular neoplasia and eradication of the lesion for those with pleomorphic lobular carcinoma in situ.




- Lobular neoplasia: morphology and management. Jorns J, Sabel MS, Pang JC. Arch Pathol Lab Med. 2014 Oct;138(10):1344-9. doi : 10.5858/arpa.2014-0278-CC Review. PMID: 25268198