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atypical hyperplasias

Monday 23 November 2015

atypical epithelial hyperplasia of the breast; mammary atypical hyperplasias


- atypical ductal hyperplasia (ADH)
- columnar cell change with atypia
- atypical lobular hyperplasia (ALH)


- atypical ductal hyperplasia (ADH)

  • ADH is important because it carries a 4-5 times relative risk of breast cancer at 10-15 yrs post biopsy.
  • Usually solitary
  • Confined to a single lobular unit
  • Seldom larger than 3mm
  • At least focally a uniform cell population and architectural features of low grade DCIS.
  • Cribriform, micropapillary or solid growth pattern
  • Secondary lumina some of which are rigid while others are tapering
  • Evenly spaced cells with hyperchromatic nuclei
  • monotonous population of epithelial cells showing rigid structure across ducts and low grade cytology.
  • Luminal microcalcifications can be present.
  • possible mucocele-like lesion

- columnar cell change with atypia

  • Columnar cell change with atypia

- atypical lobular hyperplasia (ALH)