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papillary thyroid carcinoma variants

Sunday 13 March 2016

Variants of Papillary Thyroid Carcinoma

Classically characterized by its papillary appearance, papillary thyroid carcinoma is the most common malignant neoplasm of the thyroid.

Several variants of papillary carcinoma have been described considering size (microcarcinoma); nature of the tumor boundaries (encapsulated); architecture (follicular, macrofollicular, cribriform-morular, solid, micropapillary); cellular characteristics (tall cell, columnar, oncocytic, clear cell, hobnail); additional tumor components (papillary carcinoma with focal insular component, papillary carcinoma with spindle and giant cell carcinoma, papillary carcinoma with squamous cell carcinoma, papillary carcinoma with mucoepidermoid carcinoma); stromal features (papillary carcinoma with fasciitis like stroma); or a combination of the abovementioned characteristics (diffuse sclerosing, Warthin-like).

Open references

- Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD. Turk Patoloji Derg. 2015;31 Suppl 1:34-47. doi : 10.5146/tjpath.2015.01313 PMID: 26177316 (Free)