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NIFTP

Sunday 13 March 2016

NIFTP: NIFVPTC; non-invasive follicular variant of papillary thyroid carcinoma; EFVPTC; encapsulated papillary thyroid carcinoma follicular variant; encapsulated follicular variant of papillary thyroid carcinoma; Non-invasive follicular thyroid neoplasm with papillary-like nuclear features

Images

- encapsulated type (EFVPTC)

- Reference digital slides from YR Nikiforov

Definition: Some findings demonstrate that if terminology is changed and NIFVPTCs is not considered carcinomas, the rates of malignancy for FNA diagnostic categories would be substantially decreased, with the most clinically significant decrease seen in the SUS category, which demonstrated a relative decrease of nearly 50%. (26114752)

Open references

- Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma. A Paradigm Shift to Reduce Overtreatment of Indolent Tumors. Nikiforov YE et al. 2016. doi : 10.1001/jamaoncol.2016.0386

- Follicular variant of papillary thyroid cancer: encapsulated, nonencapsulated, and diffuse: distinct biologic and clinical entities. Gupta S, Ajise O, Dultz L, Wang B, Nonaka D, Ogilvie J, Heller KS, Patel KN. Arch Otolaryngol Head Neck Surg. 2012 Mar;138(3):227-33. doi : 10.1001/archoto.2011.1466 PMID: 22431868 (Free)

- Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors. Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA. JAMA Oncol. 2016 Apr 14. doi : 10.1001/jamaoncol.2016.0386 PMID: 27078145

References

- The Impact of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma on Rates of Malignancy for Fine-Needle Aspiration Diagnostic Categories. Strickland KC, Howitt BE, Marqusee E, Alexander EK, Cibas ES, Krane JF, Barletta JA. Thyroid. 2015 Sep;25(9):987-92. doi : 10.1089/thy.2014.0612 PMID: 26114752

- Invasion rather than nuclear features correlates with outcome in encapsulated follicular tumors: further evidence for the reclassification of the encapsulated papillary thyroid carcinoma follicular variant. Ganly I, Wang L, Tuttle RM, Katabi N, Ceballos GA, Harach HR, Ghossein R. Hum Pathol. 2015 May;46(5):657-64. doi : 10.1016/j.humpath.2015.01.010 PMID: 25721865

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