- Human pathology

Home > E. Pathology by systems > Skin > acantholytic dermatoses

acantholytic dermatoses

Tuesday 15 March 2016

Grover disease


- pemphigus
- transient acantholytic dermatosis (or Grover disease)

  • It is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis, with or without dyskeratosis.
  • Once confirmed, most cases of Grover’s disease last six to twelve months, which is why it was originally called "transient".
  • However it may last much longer.
  • Nevertheless, it is not to be confused with relapsing linear acantholytic dermatosis.

- linear acantholytic dermatosis

Synopsis :

- acantholysis

  • loss of desmosomal attachment
  • acantholysis with separation of malpighian cells


- Macroscopy : transient acantholytic dermatosis (or Grover disease)

- Microscopy : transient acantholytic dermatosis (or Grover disease)

See also

- cutaneous diseases
-  cutaneous anomalies