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ramucirumab

Tuesday 15 March 2016

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Ramucirumab (IMC-1121B, trade name Cyramza) is directed against the vascular endothelial growth factor receptor 2 (VEGFR2).

By binding to VEGFR2 it works as a receptor antagonist blocking the binding of vascular endothelial growth factor (VEGF) to VEGFR2. VEGFR2 is known to mediate the majority of the downstream effects of VEGF in angiogenesis.

It is a fully human monoclonal antibody (IgG1) developed for the treatment of solid tumors. This drug was developed by ImClone Systems Inc. It was isolated from a native phage display library from Dyax.

Clinical trials

- mammary adenocarcinoma (breast cancer)
- hepatocellular carcinoma (HCC)
- urothelial carcinoma