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eosinophilic, solid, and cystic renal cell carcinoma

Tuesday 15 March 2016

ESC RCC; ESC renal cell carcinoma

Definition: This renal neoplasm characterized by eosinophilic cytoplasm and solid and cystic growth has been reported in patients with tuberous sclerosis complex (TSC).


- Wikimedia: eosinophilic, solid and cystic renal cell carcinoma

Although similar to this subset of renal cell carcinomas (RCCs) seen in TSC, it has been proposed that sporadic "eosinophilic, solid, and cystic RCC," (ESC RCC) as a specific entity.

It occurs predominantly in female individuals and is characterized by distinct morphologic features, predominant CK20-positive/CK7-negative immunophenotype, and indolent behavior.


- gains

  • 7p21.2-7q36.2
  • 16p13.3-16q23.1

- losses

  • Xp11.21


- Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. Trpkov K, Hes O, Bonert M, Lopez JI, Bonsib SM, Nesi G, Comperat E, Sibony M, Berney DM, Martinek P, Bulimbasic S, Suster S, Sangoi A, Yilmaz A, Higgins JP, Zhou M, Gill AJ, Przybycin CG, Magi-Galluzzi C, McKenney JK. Am J Surg Pathol. 2016 Jan;40(1):60-71. doi : 10.1097/PAS.0000000000000508 PMID: 26414221