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Thursday 7 April 2016

EBU FNA; Endobronchial ultrasound fine-needle aspiration biopsy

Definition: EBUS-FNA is the acronym of Endobronchial ultrasound fine-needle aspiration biopsy.


- 4L lymph node metastatic papillary renal cell carcinoma

- benign bronchial cells at EBUS : cilia, terminal bar, columnar cells, small groups

- SCC EBUS-FNA ThinPrep & Cellblock

Linear endosonography, including intrathoracic lymph nodal sampling by endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) and endoesophageal ultrasound fine-needle aspiration (EUS-FNA), has an important role in the diagnosing and staging of lung cancer.

Furthermore, endosonography is applied in the mediastinal evaluation of sarcoidosis, lymphoma, cysts, and nodal metastases of extrathoracic malignancies.

Endosonography-related complications as well as sedation and training strategies are discussed. The purpose of this review is to summarize current practice, recent advances, and future directions.

Endosonography is generally accepted as a powerful and safe diagnostic test for various diseases affecting the mediastinum. Large-scale implementation is needed.



Open References

- Endobronchial ultrasound fine-needle aspiration biopsy of pulmonary non–small cell carcinoma with subclassification by immunohistochemistry panel. Brian T. Collins, 2012. doi : 10.1002/cncy 21222

- Ultrasound techniques in the evaluation of the mediastinum, part I: endoscopic ultrasound (EUS), endobronchial ultrasound (EBUS) and transcutaneous mediastinal ultrasound (TMUS), introduction into ultrasound techniques. Dietrich CF, Annema JT, Clementsen P, Cui XW, Borst MM, Jenssen C. J Thorac Dis. 2015 Sep;7(9):E311-25. doi : 10.3978/j.issn.2072-1439.2015.09.40 PMID: 26543620 (Free)

- Ultrasound techniques in the evaluation of the mediastinum, part 2: mediastinal lymph node anatomy and diagnostic reach of ultrasound techniques, clinical work up of neoplastic and inflammatory mediastinal lymphadenopathy using ultrasound techniques and how to learn mediastinal endosonography. Jenssen C, Annema JT, Clementsen P, Cui XW, Borst MM, Dietrich CF. J Thorac Dis. 2015 Oct;7(10):E439-58. doi : 10.3978/j.issn.2072-1439.2015.10.08 PMID: 26623120 (Free)

- Choose the best route: ultrasound-guided transbronchial and transesophageal needle aspiration with echobronchoscope in the diagnosis of mediastinal and pulmonary lesions. Mondoni M, D’adda A, Terraneo S, Carlucci P, Radovanovic D, Di Marco F, Santus P. Minerva Med. 2015 Nov 19. PMID: 26583285 (Free)

- Utility of endobronchial ultrasound-guided-fine-needle aspiration and additional value of cell block in the diagnosis of mediastinal granulomatous lymphadenopathy.
Zaidi SN, Raddaoui E. Cytojournal. 2015 Sep 22;12:20. doi : 10.4103/1742-6413.16594 PMID: 26445590 (Free)

- Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): an overview and update for the cytopathologist. VanderLaan PA, Wang HH, Majid A, Folch E. Cancer Cytopathol. 2014 Aug;122(8):561-76. doi : 10.1002/cncy.21431 PMID: 24760496 (Free)

- Outcome of patients with negative and unsatisfactory cytologic specimens obtained by endobronchial ultrasound-guided transbronchial fine-needle aspiration of mediastinal lymph nodes. Mehta HJ, Tanner NT, Silvestri G, Simkovich SM, Shamblin C, Shaftman SR, Nietert PJ, Yang J. Cancer Cytopathol. 2015 Feb;123(2):92-7. doi : 10.1002/cncy.21482 PMID: 25186645 (Free)

- Evaluation of endobronchial ultrasound-guided fine-needle aspirations (EBUS-FNA): correlation with adequacy and histologic follow-up. Karunamurthy A, Cai G, Dacic S, Khalbuss WE, Pantanowitz L, Monaco SE. Cancer Cytopathol. 2014 Jan;122(1):23-32. doi : 10.1002/cncy.21350 PMID: 24127207 (Free)