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cutaneous lymphoepithelial carcinoma

Friday 8 April 2016

Lymphoepithelial carcinoma is a relatively common malignancy in the nasopharynx, but it rarely occurs in other sites. Cutaneous locations have been reported.

Histopathologically, the tumors consisted of multiple well-circumscribed dermal-hypodermal nodules composed of aggregates of undifferentiated malignant cells.

These cells had moderate amounts of eosinophilic cytoplasm and vesicular nuclei with prominent nucleoli. There was no squamous or glandular differentiation.

For each case, a heavy lymphoplasmacytic infiltrate was found. No dysplasia was noted in the epidermis.

In one case, the tumoral component showed numerous Sternberg-like cells scattered within a lymphocytic background. This case might be mistaken with a Hodgkin’s lymphoma.

No Epstein-Barr viral genomic sequences were detected by in situ hybridization. This negativity for Epstein-Barr virus may be a help in the differential diagnosis from metastatic undifferentiated nasopharyngeal carcinoma.


- Lymphoepithelioma-like carcinoma of the skin: a report of 3 Epstein-Barr virus (EBV)-negative additional cases. Immunohistochemical study of the stroma reaction. Ferlicot S, Plantier F, Rethers L, Bui AD, Wechsler J. J Cutan Pathol. 2000 Jul;27(6):306-11. PMID: 10885408