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HPV-associated anal neuroendocrine carcinoma

Friday 8 April 2016

Neuroendocrine carcinoma (NEC) of the anal canal is exceedingly rare and its histogenesis is poorly understood.

SIN may be a precursor of anal canal NEC and that HPV18 may play an important role in the histogenesis of anal canal NEC, similar to its role in cervical NEC.

References

- Anal canal neuroendocrine carcinoma associated with squamous intraepithelial neoplasia: a human papillomavirus 18-related lesion. Ohtomo R, Sekine S, Taniguchi H, Tsuda H, Moriya Y, Kushima R. Pathol Int. 2012 May;62(5):356-9. doi : 10.1111/j.1440-1827.2012.02800.x PMID: 22524667