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clathrin-coated vesicles

Friday 28 November 2003

Clathrin-coated vesicles (CCVs) play important roles in nutrient uptake, downregulation of signaling receptors, pathogen invasion and biogenesis of endosomes and lysosomes.

Membrane sorting between secretory and endocytic organelles is predominantly controlled by small carrier vesicles or tubules that have specific protein coats on their cytoplasmic surfaces.

Clathrin-clathrin-adaptor coats function in many steps of intracellular transport.

See also

- endocytic CCV formation have emerged
- CCV formation at the Golgi
- endosomes and endocytic CCV formation
- ENTH/ANTH proteins
- clathrin adaptator proteins


- Edeling MA, Smith C, Owen D. Life of a clathrin coat: insights from clathrin and AP structures. Nat Rev Mol Cell Biol. 2006 Jan;7(1):32-44. PMID: 16493411

- Robinson MS. Adaptable adaptors for coated vesicles. Trends Cell Biol. 2004 Apr;14(4):167-74. PMID: 15066634

- Duncan MC, Payne GS. ENTH/ANTH domains expand to the Golgi. Trends Cell Biol. 2003 May;13(5):211-5. PMID: 12742163

- Smythe E. Regulating the clathrin-coated vesicle cycle by AP2 subunit phosphorylation. Trends Cell Biol. 2002 Aug;12(8):352-4. PMID: 12191904