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intranodal palisaded myofibroblastoma

Friday 29 April 2016

INPM

Definition: Intranodal palisaded myofibroblastoma is a benign, lymph node-based myofibroblastic tumor of unknown pathogenesis.

Images

- intranodal palisaded myofibroblastoma

IHC: +SMA / -S100. NB: resembles schwannoma; collagen ’mats’; abundant haemosiderin (PMID: 2712186).

Synopsis

- Verocay-like structures
- smooth muscle actin +
- S100 -
- RBCs
- thick collagen

Molecular biology

Mutational activation of the β-catenin gene is likely a pivotal event in the pathogenesis of intranodal palisaded myofibroblastoma. (25025452)

Open references

- Intranodal palisaded myofibroblastoma: another mesenchymal neoplasm with CTNNB1 (β-catenin gene) mutations: clinicopathologic, immunohistochemical, and molecular genetic study of 18 cases. Laskin WB, Lasota JP, Fetsch JF, Felisiak-Golabek A, Wang ZF, Miettinen M. Am J Surg Pathol. 2015 Feb;39(2):197-205. doi : 10.1097/PAS.0000000000000299 PMID: 25025452 (Free)

Paywall references

- Palisaded myofibroblastoma. A benign mesenchymal tumor of lymph node.
Weiss SW, Gnepp DR, Bratthauer GL.
Am J Surg Pathol. 1989 May;13(5):341-6.
PMID: 2712186